Intended for use by government officials, and those working for regulatory bodies and operating organizations, this publication will assist in the application of IAEA Safety Standards Series No. GSR Part 3 in relation to the concept of exemption of practices or sources within practices from regulatory control. It addresses the application of a graded approach to the concept of exemption through the use of generic exemption and specific exemption. It explains the concept of exclusion and its relationship to exemption and clearance. The recommendations provided in this publication are applicable to all facilities and activities that use, manufacture, process, trade or store radioactive sources or material containing either natural or artificial radionuclides. The Safety Guide primarily addresses exemption from regulatory control in planned exposure situations. Although, the concept of exemption is only applicable to planned exposure situations, guidance on the application of a screening approach for decision making in managing certain existing exposure situations is also provided.