This book addresses the question of how the American continent engages with various forms of interregionalism, including how different regions within the Americas deal with other regions of the world as well as how they relate among themselves. The presence of different political, economic, and cultural sub-regions within the Americas makes the continent a perfect setting to explore differences and commonalities in the western hemisphere’s relationship with other regions across the globe. Interregionalism and the Americas tackles three unifying questions. First, what type and understanding of interregionalism characterize the Americas’ way to interregionalism, if any? Second, is summitry ultimately the major visible feature of interregionalism in the Americas and beyond? Third, is there anything typical or characteristic in the way in which the Americas engage with interregionalism? This book contributes both to the theoretical debates about interergionalism and to the empirical understanding of the phenomenon and makes a compelling case to strengthen the inter-American system and to advance a “trilateral interregionalism” mechanism between North America, Latin America, and Europe to stand up for their common values, norms, and preferred international order.