Twenty-FirstCentury Issues: Perspectives of Pandemic, Climate Change, and Digital Transformationis a stimulating compilation of work that addresses the Twentieth Century’s dichotomy and relationship to the Twenty-First Century as a result of global challenges impacting health, economics, and digital transformation. The focal point of this research is aggressively making researchers level up scientific advancements to harness needed resources. Twenty-First Century science and technology research is vital to meeting a broad range of global challenges related to economic growth, better health, sustainable development and enhanced safety and security This compilation of work gives readers insight about preparation for world improvements and how to meet the futuristic needs of civilization.